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Lecture

Engineering Li-delivering bioactive glass-ceramic scaffolds for regenerative medicine

Thursday (27.09.2018)
12:30 - 12:45 S1/01 - A02
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Since lithium (Li+) plays a role in angiogenesis, the localized and controlled release of Li+ ions from bioactive glasses (BGs) represents a promising alternative therapy for tissue engineering and repair of vascularized tissues. This presentation will review recent advances in the development of Li-containing bioactive glass-ceramic scaffolds derived from the 45S5 BG and their in vitro angiogenic potential. It has been demonstrated that ion release from Li-substituted BG can be tailored to induce an appropriate biological response, for example, the partial replacement of Na2O by up to 5 wt% of Li2O in the 45S5 BG ensures the release of Li+ within the therapeutic range for humans (0.5-1.2 mmol). Recent experimental results have shown that human umbilical vein endothelial cells (HUVECs) treated with ion dissolution products (IDPs) of glass-ceramic scaffolds containing 5 wt% of Li2O (45S5.5Li) exhibit a proliferative and migratory response and have the capacity to form tubules in vitro. In addition, the activation of the Wnt/β-catenin canonical pathway was observed. At 24 h post-stimulation, the expression of β-catenin in HUVECs treated with IDPs of the bioactive glass-ceramic scaffolds 45S5.5Li showed a statistically significant increase in comparison to the control, with an equivalent response to that obtained with the use of 0.60 mmol LiCl and M199 medium supplemented with VEGF.

Moreover Li+ ions also promote osteogenesis and bone repair. In this context, new Li-delivering bioactive glass-ceramic scaffolds could further represent a promising biomaterial-based strategy to initiate angiogenesis and to induce desirable bone regeneration.

 

Speaker:
Prof. Dr. Aldo R. Boccaccini
Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
Additional Authors:
  • Dr. Luis Haro Durand,
    Instituto de Biología y Medicina Experimental IByME / CONICET
  • Valentina Miguez-Pacheco
    Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
  • Dr. Alejandro Gorustovich
    INTECIN UBA-CONICET