No thermodynamic data for liquid Ag-Li-Sb alloys were published in the literature yet. The partial and integral enthalpies of mixing of liquid Ag-Li-Sb alloys at 980 K were determined applying drop calorimetry. The investigations were performed along five sections by the addition of lithium to mixtures with fixed Ag to Sb molar ratio of 1:1 and 1:4 and by the addition of silver to mixtures with fixed Li to Sb molar ratio equal to 1:9, 3:7 and 1:1. Integral enthalpy of mixing in Ag-Li-Sb alloys strongly depends on composition. Negative enthalpy of mixing is observed throughout the entire range of concentrations studied. Experimental data were compared and discussed with Muggianu and Toop extrapolation models. The Toop model shows much better fit to the experimental results than the Muggianu model. The Toop model confirms the strong asymmetry of the enthalpy of mixing of Ag-Li-Sb liquid alloys. In addition, liquidus position was deduced from discontinuities in partial and kinks in integral enthalpies.