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Electrospun polymer matrices for drug delivery and tissue engineering applications

Thursday (27.09.2018)
11:45 - 12:00 S1/01 - A02
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In the last decade, electrospinning technology has attracted a huge attention as a convenient processing method for the fabrication of nanofibrous structures for a number of bio/nanotechnological applications. Plain, drug-loaded or surface modified electrospun nanofibers scaffolds for tissue engineering and drug delivery are among the most explored systems. Electrospun biopolymer matrices and pH-responsive nanofibrous membranes developed by Argentinean and German students under IDEAR exchange program (Friedrich-Alexander-Universität of Erlangen-Nuremberg and Universidad Nacional Mar del Plata), are presented.

Zein-based electrospun nanofibers were obtained using benign solvents. The electrospinnability conditions of zein, zein/poly(glycerol sebacate) (PGS) and zein/poly(epsilon-caprolactone) (PCL) blends were explored. Blending zein with synthetic polymers improved degradation behavior in aqueous environment and mechanical properties.

Soy protein isolated (SPI) and SPI/gelatin blends were successfully electrospun using poly(ethylene oxide) as polymer carrier. The obtained matrices were completely characterized. Furthermore, to avoid the solubility in water and to tailor their degradability, a cross-linking process by photopolymerization was performed.

Nitrofurazone (NFZ) loaded Eudragit® S100 (ES100) nanofibrous membranes were fabricated as pH-responsive targeted drug delivery systems for wound healing. The electrospinnability of different polymer solutions and the morphology of the resulting nanofibers were studied. Uniform drug-loaded nanofibers without beads were obtained. NFZ was efficiently loaded in the nanofibers. Evaluation of the NFZ release profiles was conducted in a range of pH (5.5 – 8). ES100 is no soluble at pH < 7 and intuitively it was expected that there is no drug release or only a very slow release under these conditions. However, the tests in acidic media revealed the release of certain NFZ in time. Indeed, at the pH of the healthy skin (pH=5.5), the NFZ release was low, but not negligible. Overall, the obtained analysis results demonstrate a high potential for site specific pH-sensitive electrospun drug delivery carriers as wound dressings, though more optimization is still required for fine tuning the dissolution rates in acidic media by manipulating the nanofibers architecture and structure.

Prof. Dr. Gustavo Abraham
Universidad Nacional de Mar del Plata UNMdP
Additional Authors:
  • Matthäus Popov
    Universidad Nacional de Mar del Plata UNMdP
  • Max Meuter
    Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
  • Agustina Massone
    Universidad Nacional de Mar del Plata UNMdP
  • Dr. Guadalupe Rivera
    Universidad Nacional de Mar del Plata UNMdP
  • Dr. Agustina Aldana
    Universidad Nacional de Mar del Plata UNMdP
  • Dr. Liliana Liverani
    Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
  • Prof. Dr. Aldo R. Boccaccini
    Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)