It is the mission of this interdisciplinary symposium to address recent advances in the development and examination of new bone substitute materials and implant materials for systemically altered bones. In the centre of attention are two diseases, whereby each of them results in a significantly heightened risk of bone fracture. Osteoporosis, which is a widespread bone degeneration disease predominantly occurring with old age, and also multiple myeloma, a malignant tumour disease, which results in localised destruction of bone tissue. Modern trauma surgery and orthopaedics can indeed avail of a variety of bone substitute materials and also of durable implants. However, those are not attuned to the specific conditions of systemic symptoms, which lead to a significant worsening of bone fracture healing and bone defect healing. The symposium will offer an excellent forum to present and discuss innovative solutions for such forms of bone defects and biomaterials.